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About Us

The State Key Laboratory of Quantitative Synthetic Biology (hereinafter referred to as the "Laboratory") is established under the Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS). Positioned at the frontier of global science and technology and guided by major national strategic missions, the Laboratory addresses synthetic biology’s core challenges: the lack of capabilities in rational design and efficient construction. It focuses on two key research pillars: the quantitative principles of life emergence and synthetic biology enabling technologies. Centered on the development of synthetic cells and engineered cells, the Laboratory aims to cultivate original innovation capabilities in synthesizing and designing life, driving transformative advances in bio‑manufacturing through synthetic biotechnology, pioneering next‑generation bio‑manufacturing solutions, and securing global leadership in synthetic biology.

The Laboratory has taken on major national tasks around synthetic and engineered cells, leading the CAS Strategic Research Program (Category B) and the National Natural Science Foundation of China’s Basic Science Center Project (Class B). Its members have headed over 35 National Key Research and Development Program projects. Over the past five years, team members have published over 150 papers in journals like Cell, Nature, Science, and their major sub‑journals, while their related achievements were selected twice consecutively among China’s top ten scientific and technological progresses, receiving 13 science and technology awards at and above provincial or ministerial levels. The Laboratory has led the construction of a major research infrastructure for synthetic biology, focused on developing three key platforms:



design‑based learning, synthesis testing, and user testing. Actively promoting the integration of technology and industry, the Laboratory has taken the lead to establish a National Bio‑manufacturing Innovation Center, collaborating with central state‑owned enterprises (SOEs), other SOEs, and leading industry players to build a complete innovation chain with upstream‑downstream collaboration spanning from original breakthroughs to industrial development.

The Institute of Synthetic Biology (hereinafter referred to as the "Institute") was established in December 2017. Since its inception, it has gathered a group of young leaders and pioneering scientists from the field of synthetic biology in China and abroad, forming a dynamic, multidisciplinary, and cutting‑edge innovation team of 1,200 members. Adhering to the philosophy of "Creating to Know, Creating to Use", the Institute systematically deploys its disciplinary efforts around the new research paradigm of "quantitative synthetic biology". On one hand, it focuses on understanding artificial life systems, conducting basic theoretical research on the quantitative understanding and rational design of life systems, and proactively laying out four research directions: synthetic biological evolution, cellular and genetic circuit design, synthetic genomics, and synthetic microbiomics,



striving to seize the high ground in the international studies of synthetic biology. On the other hand, leveraging Shenzhen's unique strengths and responding to global and domestic trends, it has established three additional research directions: materials synthetic biology, synthetic biochemistry, and synthetic immunology, focusing on the key technologies and industrial applications of synthetic biology. Corresponding to these seven core research directions, seven research centers have been established that work in coordination and complementarity, striving to become an internationally influential research and development base and industrial innovation hub for synthetic biology.

SIAT was established in 2006 by CAS, the Shenzhen Municipal People’s Government, and The Chinese University of Hong Kong. As a national strategic scientific and technological force established by CAS in the Guangdong‑Hong Kong‑Macao Greater Bay Area, SIAT is committed to strengthening the nation through science and technology. To best serve major national needs, advance integral science and technology frontiers, and support regional economic development, SIAT emphasizes three main research directions: medical imaging equipment and scientific instruments, synthetic biology and bio‑manufacturing, and integrated circuit materials and packaging. It also pursues five key scientific research directions: brain‑computer interfaces and intelligent systems; brain decoding and primate models; medical devices and medical equipment; intelligent medicine and health data; and advanced materials and carbon neutrality. Additionally, SIAT leads the construction of the National Innovation Center for Advanced Medical Devices and the National Innovation Center for Bio‑manufacturing Industry, striving

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🏢 The State Key Laboratory of Quantitative Synthetic Biology
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