Hybrid - Mexico City

At ICON Strategic Solutions, you will work in a sponsor-dedicated model, supported by ICON’s integral expertise.

As the world’s largest FSP organisation, with over 90 sponsor partnerships, we offer stability, career development and a collaborative environment where your work contributes to the development of treatments that benefit patients worldwide.

The Site Activation Manager is a sponsor-dedicated role delivered through a partnership with ICON and responsible for United States study start-up and amendment activities. The role builds strong relationships with investigative sites, drives essential document collection and quality review, supports country and site ICF development and negotiation, ensures IRB submission readiness and approval follow-up, manages amendment implementation, and partners cross-functionally to achieve timely site activation and amendment implementation.

What You Will Do

Your focus will be on coordinating site start-up and activation delivery, resolving issues, and developing team capability.

Key Responsibilities Include





• Build strong working relationships with investigative sites and support a positive sponsor-site experience throughout start-up.
• Collect, review, QC, and file essential documents required for submission and activation.
• Review and negotiate ICF changes with sites and stakeholders; manage translations, checklists, filing, and amendment updates as required.
• Ensure IRB submissions are made and approval documentation is complete and activation-ready.
• Support regulatory and clinical trial start-up activities across the US, including coordination of submission, approval, and study activation workflows.
• Collaborate with sites and internal stakeholders to set and achieve Regulatory Greenlight (RGL) goals that support timely site activation.
• Escalate risks, manage timelines, and maintain accurate documentation and tracking in systems such as CTMS and the eTMF.
• Manage protocol amendments and re

📌 Site Activation Manager (Ciudad de México)
🏢 ICON San Antonio
📍 Ciudad de México